Tag Archives: miRNA

Sichuan Agricultural University and LC Sciences Uncover the Epigenetics of Obesity

Released on: May 29, 2012, 3:24 am
Author: Chris Hebel
Industry: Biotech

Hangzhou, ChinaMay 29, 2012, 3:24 am — /EPR NETWORK/ — In a new study published online in Nature Communications, researchers from Sichuan Agricultural University and LC Sciences report the miRNAome in porcine adipose and muscle tissues. The report provides a valuable epigenomic source for obesity prediction and prevention and furthers the development of pig as a model organism for human obesity research1.

more…

Enabling microRNA Discoveries – 250th Peer-Reviewed Publication Made Possible By µparaflo® Custom Microarray Technology

Released on: June 09, 2011, 1:42 pm
Author: Chris Hebel
Industry: BiotechHealthcare

LC Sciences, a life sciences company leading the development of innovative microRNA (miRNA) analysis and discovery technologies, announced today the publication of over 250 peer-reviewed studies using the company’s microarray service for analyzing miRNA expression profiles. These studies, by leading researchers in the field, represent significant steps toward realizing these small regulatory RNA’s potential as biomarkers and therapeutic targets.

MiRNAs have proven to be an extremely important part of the gene expression regulation mechanism of a wide variety of cellular processes. This is evident in the amount of relevant findings by LC Sciences’ customers being translated into published reports and the diverse range of study areas that these publications encompass: cancer research, neuroscience, cardiovascular research, reproductive biology, plant science, microbiology, immunology and stem cell research. LC Sciences’ miRNA profiling service, powered by its µParaflo® custom microarray technology, provides quick, reliable, fully analyzed datasets enabling researchers to immediately move forward with groundbreaking research.

more…

The Porcine microRNAome is Revealed

Released on: August 20, 2010, 4:44 am
Author: Chris Hebel
Industry: Biotech

Results blaze a trail for advancement in pig biology as well the use of pigs as model organism for human biological and biomedical studies

Houston (August 20, 2010) Researchers from LC Sciences LLC and a collaboration of Universities1 have established a porcine microRNAome, a complete catalog of all microRNAs expressed in the species Sus scrofa2. MicroRNAs (miRNAs) are small regulatory RNA molecules known to control a wide array of cellular functions such as growth and development and whose dysregulation has been associated with disease. The findings of this study lay the groundwork for a greater understanding of the species through further mapping of tissue- and stage-specific miRNAs.

The domestic pig is an important species from various standpoints. First, it is a major protein source in the human diet world-wide. Additionally, its anatomy, physiology, and genome size are very similar to the human species, and there has been increasing molecular genetic evidence showing the comparability of human and pig, making it a suitable model system for human biology. Pigs are now model animals for biomedical research of cardiovascular, immunological, cancer, diabetes, and a range of other diseases. Finally, the pig has become an important source of organs and tissue for transplantation into humans.

more…

LC Sciences Pairs Deep Sequencing with Customized Microarrays to Offer New Seq-ArraySM Service for Discovery & Profiling Applications

Released on: March 19, 2010, 8:43 am
Author: Chris Hebel
Industry: Biotech

HOUSTON – Mar 19, 2010 – LC Sciences today announced the launch of its new Seq-ArraySM services designed to take full advantage of both the latest deep sequencing capabilities and the proven genomics tool – microarray. This combination of technologies advances microRNA research to the next level of depth and understanding that was not possible before with either of the technologies alone. LC Sciences has been a leading provider of microRNA discovery and profiling services since 2005.

microRNA is a young, dynamic field of study and though significant discoveries are being made every day, the very complex regulatory mechanisms of these small RNAs are still not fully understood. Continued advancement requires adaptable, even customizable research tools that can keep pace with the rapidly advancing research in this field. While deep sequencing yields results that broadly cover genome-wide miRNAs from samples of various origins, the relatively high cost and low throughput nature of sample handling, makes the systematic follow through of the sequencing discoveries for validation and/or profiling in a reproducible manner time consuming and expensive. Microarrays have achieved wide acceptance as the preferred tool to systematically profile and compare the gene expression of large numbers of samples rapidly, reproducibly, and cost effectively; however they are dependent on previously known sequence information. Seq-ArraySM is a combination of these technologies that maximizes the effectiveness of each method while overcoming the limitations of the other.

more…

LC Sciences First miRNA Microarray Service Provider to Offer Plant MicroRNA Database (PMRD) Probe Content


Released on: October 15, 2009, 11:47 am
Author: LC Sciences
Industry: Biotech

Taking full advantage of its flexible µParaflo® Biochip Technology, Houston based LC Sciences today announced immediate availability of probe content from the newly created Plant MicroRNA Database (PMRD) for their microRNA (miRNA) microarray customers . This announcement comes immediately following a publication in Nucleic Acids Researchintroducing the public database 1 . The PMRD integrates available plant miRNA data deposited in other public databases, gleaned from the recent literature, and data generated by the database organizers. It is freely available at http://bioinformatics.cau.edu.cn/PMRD.

more…

Enabling microRNA Discoveries – LC Sciences Tops 100th Customer Publication

Released on: September 4, 2009, 4:28 am
Author: LC Sciences LLC
Industry: Biotech

Houston, TX – LC Sciences announced today the publication of the 100th peer-reviewed study by one of its customers using the company’s microarray service for analyzingmicroRNA (miRNA) expression profiles and for discovery of novel small RNAs. These studies, by leading researchers in the field, contribute to a fast growing body of knowledge defining this recently discovered class of regulatory RNAs.

To date, miRNAs have proven to be extremely important part of the gene expression regulation mechanism. Expression profiling and functional studies conducted so far indicate that miRNAs participate in the regulation of almost every cellular process investigated and this is evident in the amount of relevant findings being translating into published reports.

The publications to date by LC Sciences’ customers span a diverse range of study areas, including cancer research, neuroscience, cardiovascular research, MicroRNA Publications reproductive biology, plant science, virology, stem cell research, immunology, and small RNA discovery. Their miRNA profiling service has provided a tool for many researchers to explore and examine a wide assortment of miRNA cellular networks and the resulting publications are often the first description of miRNA activity in these systems.

more…